Derl2 Gene Summary [Mouse]
Predicted to enable signal recognition particle binding activity. Acts upstream of or within retrograde protein transport, ER to cytosol and suckling behavior. Located in early endosome; endoplasmic reticulum; and late endosome. Is expressed in yolk sac and yolk sac endoderm. Orthologous to human DERL2 (derlin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Derl2 |
| Official Name | Der1-like domain family, member 2 [Source:MGI Symbol;Acc:MGI:2151483] |
| Ensembl ID | ENSMUSG00000018442 |
| Bio databases IDs | |
| Aliases | Der1-like domain family, member 2 |
| Synonyms | CGI-101, Der1-like domain family, member 2, Derlin-2, DERtrin-2, F-LAN-1, F-LANa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Derl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal recognition particle binding
- binding protein
- protein binding
- Rhomboid family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholangiocarcinoma cancer
- neoplasia
- hypoglycemia
- organismal death
- dyspnea
- cholangiocarcinoma
- cachexia
role in cell
- expression in
- proliferation
- apoptosis
- colony formation
- growth
- S phase
- abnormal morphology
- endoplasmic reticulum stress response
- transport in
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Derl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- endoplasmic reticulum unfolded protein response
- suckling behavior
- positive regulation of cell proliferation
- retrograde protein transport, ER to cytosol
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome
- membrane
- late endosome
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- signal recognition particle binding