Txndc5 Gene Summary [Mouse]
Enables protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; eye; immune system; intestine; and male reproductive gland or organ. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Txndc5 |
| Official Name | thioredoxin domain containing 5 [Source:MGI Symbol;Acc:MGI:2145316] |
| Ensembl ID | ENSMUSG00000038991 |
| Bio databases IDs | |
| Aliases | thioredoxin domain containing 5 |
| Synonyms | ENDOPDI, ERP46, HCC-2, PC-TRP, PDIA15, STRF8, thioredoxin domain containing 5, TLP46, TXND5, UNQ364 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Txndc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- protein disulfide isomerase, eukaryotic
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein disulfide-isomerase domain
- enzyme
- protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glycogen storage disease type II
- early onset hypertension
- bleomycin-induced pulmonary fibrosis
- idiopathic pulmonary fibrosis
role in cell
- apoptosis
- proliferation
- expression in
- activation in
- degradation in
- growth
- accumulation
- aggregation
- survival
- peroxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Txndc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- endoplasmic reticulum
- lysosomal lumen
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide oxidoreductase activity
- protein disulfide isomerase activity