Vwa2 Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within calcium-independent cell-matrix adhesion. Located in basement membrane and extracellular space. Is expressed in several structures, including bone; lung; metanephros; skin; and tooth. Orthologous to human VWA2 (von Willebrand factor A domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vwa2 |
| Official Name | von Willebrand factor A domain containing 2 [Source:MGI Symbol;Acc:MGI:2684334] |
| Ensembl ID | ENSMUSG00000025082 |
| Bio databases IDs | |
| Aliases | von Willebrand factor A domain containing 2 |
| Synonyms | AMACO, CCSP-2, NET42, RGD1562000, von Willebrand factor A domain containing 2, Vwa2-ps1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vwa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP)
- vWFA
- Human growth factor-like EGF
- von Willebrand factor type A domain
- protein binding
- identical protein binding
- EGF_CA
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vwa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-matrix adhesion
- regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding