Dynlt2b Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in intraciliary retrograde transport and regulation of intraciliary retrograde transport. Predicted to be located in ciliary base; cytoskeleton; and dynein axonemal particle. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Is expressed in embryo and forelimb bud. Used to study spermatogenic failure. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dynlt2b |
| Official Name | dynein light chain Tctex-type 2B [Source:MGI Symbol;Acc:MGI:1913311] |
| Ensembl ID | ENSMUSG00000014075 |
| Bio databases IDs | |
| Aliases | dynein light chain Tctex-type 2B |
| Synonyms | 0610012D17Rik, 2410011K15Rik, dynein light chain Tctex-type 2B, RGD1563597, SRTD17, TCTEX1D2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dynlt2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tctex-1 family
- dynein light chain (DLC)-like domain superfamily
- dynein intermediate chain binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- short-rib thoracic dysplasia type 17 with or without polydactyly
- digenic short rib thoracic dysplasia 3/6 with polydactyly
- short-rib thoracic dysplasia type 17 with polydactyly
- short-rib thoracic dysplasia 17 without polydactyly
role in cell
- binding in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- axonemes
- microtubule organizing centers
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dynlt2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- microtubule-based movement
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasmic dynein complex
- interphase microtubule organizing center
- cytoplasm
- spindle pole
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein intermediate chain binding