Ptpn3 Gene Summary [Mouse]
Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Predicted to be involved in several processes, including negative regulation of membrane protein ectodomain proteolysis; regulation of membrane depolarization during action potential; and regulation of sodium ion transmembrane transporter activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in several structures, including cranial ganglion; gut; nasal epithelium; submandibular gland primordium; and urinary system. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn3 |
| Official Name | protein tyrosine phosphatase, non-receptor type 3 [Source:MGI Symbol;Acc:MGI:105307] |
| Ensembl ID | ENSMUSG00000038764 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 3 |
| Synonyms | 9530011I20Rik, protein tyrosine phosphatase non-receptor type 3, protein tyrosine phosphatase, non-receptor type 3, PTPCL, PTP-H1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- canonical PDZ domain
- phosphotyrosine binding
- sodium channel regulator
- protein binding
- PTP_DSP_cys
- Pleckstrin homology-like domain
- PDZ domain
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- FERM N-terminal domain
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- ATPase binding
- Protein-tyrosine phosphatase
- Ubl1_cv_Nsp3_N-like
- phosphatase
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the Ptpn3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Huntington disease
- chronic obstructive pulmonary disease
- pancreatic adenocarcinoma
- coronary artery disease
- breast cancer
- metastatic breast cancer
- endometriosis
- pancreatic epithelial cancer
role in cell
- phosphorylation in
- expression in
- migration
- invasion by
- proliferation
- binding in
- mitosis
- colony formation
- accumulation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- negative regulation of membrane protein ectodomain proteolysis
- regulation of sodium ion transmembrane transporter activity
- protein dephosphorylation
- negative regulation of mitotic cell cycle
- negative regulation of epidermal growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- sodium channel regulator activity
- protein binding
- protein tyrosine phosphatase activity
- cytoskeletal protein binding
- ATPase binding