Trub1 Gene Summary [Mouse]
Predicted to enable pre-miRNA binding activity and pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis; positive regulation of pre-miRNA processing; and tRNA modification. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in pectoral girdle and thoracic body wall musculature and testis. Orthologous to human TRUB1 (TruB pseudouridine synthase family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trub1 |
| Official Name | TruB pseudouridine (psi) synthase family member 1 [Source:MGI Symbol;Acc:MGI:1919383] |
| Ensembl ID | ENSMUSG00000025086 |
| Bio databases IDs | |
| Aliases | TruB pseudouridine (psi) synthase family member 1 |
| Synonyms | 2610009I02RIK, 9030425C13Rik, C76870, PUS4, TruB pseudouridine (psi) synthase family member 1, TruB pseudouridine synthase family member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trub1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TruB family pseudouridylate synthase (N terminal domain)
- PseudoU_synth
- pseudouridine synthase
- enzyme
- protein binding
- tRNA pseudouridine(55) synthase
- RNA binding
- tRNA pseudouridylate synthase B C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trub1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of pre-miRNA processing
- mRNA processing
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- pre-miRNA binding
- pseudouridine synthase activity