Ube2v2 Gene Summary [Mouse]
Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ube2v2 |
| Official Name | ubiquitin-conjugating enzyme E2 variant 2 [Source:MGI Symbol;Acc:MGI:1917870] |
| Ensembl ID | ENSMUSG00000022674 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2 variant 2 |
| Synonyms | 1110021H13RIK, 4632410D19Rik, 5730524P06Rik, 6820402M05, DDVIT1, EDAF-1, EDPF-1, MMS2, ubiquitin conjugating enzyme E2 V2, ubiquitin-conjugating enzyme E2 variant 2, UEV-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2v2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2v2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
role in cell
- apoptosis
- cell death
- formation
- formation in
- development
- neurite outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2v2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA double-strand break processing
- regulation of DNA repair
- protein polyubiquitination
- error-free postreplication DNA repair
- protein K63-linked ubiquitination
- positive regulation of double-strand break repair
- postreplication repair
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- UBC13-MMS2 complex
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding