TRUB1 Gene Summary [Human]
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRUB1 |
| Official Name | TruB pseudouridine synthase family member 1 [Source:HGNC Symbol;Acc:HGNC:16060] |
| Ensembl ID | ENSG00000165832 |
| Bio databases IDs | |
| Aliases | TruB pseudouridine synthase family member 1, probable tRNA pseudouridine synthase 1 |
| Synonyms | 2610009I02RIK, 9030425C13Rik, C76870, PUS4, TruB pseudouridine (psi) synthase family member 1, TruB pseudouridine synthase family member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRUB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TruB family pseudouridylate synthase (N terminal domain)
- PseudoU_synth
- pseudouridine synthase
- enzyme
- protein binding
- tRNA pseudouridine(55) synthase
- RNA binding
- tRNA pseudouridylate synthase B C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRUB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of pre-miRNA processing
- mRNA processing
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- pre-miRNA binding
- pseudouridine synthase activity