Bnc1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity and rDNA binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell proliferation; regulation of DNA-templated transcription; and wound healing. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; branchial arch; gonad; outer layer of bladder; and skin. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin zinc finger protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bnc1 |
| Official Name | basonuclin 1 [Source:MGI Symbol;Acc:MGI:1097164] |
| Ensembl ID | ENSMUSG00000025105 |
| Bio databases IDs | |
| Aliases | basonuclin 1 |
| Synonyms | basonuclin zinc finger protein 1, bn1, BNC, BSN1, HsT19447, POF16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bnc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- zinc finger domain
- ribosomal DNA (rDNA) binding protein
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cellulitis
- abscess
- cannabis dependence
- premature ovarian failure type 16
- androgenic alopecia
- serous ovarian adenocarcinoma
- serous ovarian cancer
- premature ovarian failure
regulates
- RNA polymerase II
- RNA polymerase I
- DNA promoter
- DNA endogenous promoter
- Pol1
- 47S PRE-RRNA
- RNR
role in cell
- proliferation
- implantation
- morphology
- organization
- maturation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bnc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of oocyte maturation
- spermatogenesis
- positive regulation of cell proliferation
- cell differentiation
- epidermis development
- regulation of transcription from RNA polymerase I promoter
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- rDNA binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription