Bik Gene Summary [Mouse]
Predicted to enable BH domain binding activity. Acts upstream of or within apoptotic mitochondrial changes; male gonad development; and spermatogenesis. Located in mitochondrial envelope. Is expressed in several structures, including genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bik |
| Official Name | BCL2-interacting killer [Source:MGI Symbol;Acc:MGI:1206591] |
| Ensembl ID | ENSMUSG00000016758 |
| Bio databases IDs | |
| Aliases | BCL2-interacting killer |
| Synonyms | BBC1, BCL2-interacting killer, BIKLK, BIP1, Blk, BP4, NBK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bik often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Bcl-2 homology 3 domain
- transmembrane domain
- protein domain specific binding
- protein binding
- Bcl2-interacting killer, BH3-domain containing
Pathways
Biological processes and signaling networks where the Bik gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- HER2 negative hormone receptor negative breast cancer
- uterine serous papillary cancer
- severe combined immunodeficiency
- primary sclerosing cholangitis
- azoospermia
role in cell
- differentiation
- survival
- cell death
- condensation
- proliferation
- activation
- quantity
- apoptosis
- autophagy in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- intracellular membranes
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bik gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic mitochondrial changes
- male gonad development
- apoptotic process
- positive regulation of release of cytochrome c from mitochondria
- regulation of apoptotic process
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- Bcl-2 family protein complex
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- protein binding