Mob2 Gene Summary [Mouse]
Predicted to enable protein kinase activator activity. Acts upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytoplasm and neuron projection terminus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mob2 |
| Official Name | MOB kinase activator 2 [Source:MGI Symbol;Acc:MGI:1919891] |
| Ensembl ID | ENSMUSG00000025147 |
| Bio databases IDs | |
| Aliases | MOB kinase activator 2 |
| Synonyms | 1110017M21Rik, 2700078K21Rik, HCCA2, LOC100360882, Mmh, MOB kinase activator 2, RGD1562983 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mob2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Mob1/phocein family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- prostatic carcinoma
- epithelial cancer
- diverticular disease
regulated by
- decitabine
- tazemetostat
- trichostatin A
- SP2509
- DNMT3A
role in cell
- activation in
- apoptosis
- binding in
- overduplication
- overduplication in
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nucleoli
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mob2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein kinase activator activity