Mob1a Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in hippo signaling. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus; lung; and spinal cord. Orthologous to human MOB1A (MOB kinase activator 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mob1a |
| Official Name | MOB kinase activator 1A [Source:MGI Symbol;Acc:MGI:2442631] |
| Ensembl ID | ENSMUSG00000043131 |
| Bio databases IDs | |
| Aliases | MOB kinase activator 1A |
| Synonyms | 4022402H07Rik, C2orf6, hMOB1, LOC100366014, MABKL1B, MATS1, MOB1, MOB4B, MOBK1B, MOB kinase activator 1A, MOBKL1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mob1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- protein binding
- Mob1/phocein family
Pathways
Biological processes and signaling networks where the Mob1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- cancer
- tumorigenesis
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- proliferation
- activation in
- apoptosis
- telophase
- fludarabine resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- centrosome
- midbody
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mob1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein phosphorylation
- hippo signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein serine/threonine kinase activator activity
- metal ion binding
- protein kinase activator activity