Kcnip2 Gene Summary [Mouse]
This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Details
| Type | Protein Coding |
| Official Symbol | Kcnip2 |
| Official Name | Kv channel-interacting protein 2 [Source:MGI Symbol;Acc:MGI:2135916] |
| Ensembl ID | ENSMUSG00000025221 |
| Bio databases IDs | |
| Aliases | Kv channel-interacting protein 2 |
| Synonyms | AI851528, KCHIP2, Kv channel-interacting protein 2, LOC100911951, potassium voltage-gated channel interacting protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- palmitoylation site
- EF-hand domain pair
- potassium channel regulator
- calcium ion binding
- EFh
- protein binding
- identical protein binding
- EF-hand domain
- binding protein
- EF hand
- ion channel binding
- A-type (transient outward) potassium channel
- Eps15 homology domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- Huntington disease
- arrhythmia
- systemic lupus erythematosus
role in cell
- expression in
- function
- excitability
- repolarization
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- Nucleus
- rough endoplasmatic reticulum
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- potassium ion transport
- detection of calcium ion
- clustering of voltage-gated potassium channels
- signal transduction
- muscle contraction
- regulation of heart contraction
- synaptic transmission
- regulation of action potential
- membrane repolarization
Cellular Component
Where in the cell the gene product is active
- dendrite
- potassium channel complex
- cytoplasm
- voltage-gated potassium channel complex
- synapse
- Kv4.2-KChIP2 channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- A-type (transient outward) potassium channel activity
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
- ER retention sequence binding
- potassium channel regulator activity
- ion channel binding