Caly Gene Summary [Mouse]
Predicted to enable clathrin light chain binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse. Is expressed in central nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human CALY (calcyon neuron specific vesicular protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Caly |
| Official Name | calcyon neuron-specific vesicular protein [Source:MGI Symbol;Acc:MGI:1915816] |
| Ensembl ID | ENSMUSG00000025468 |
| Bio databases IDs | |
| Aliases | calcyon neuron-specific vesicular protein |
| Synonyms | 0710001P07Rik, 1110004A22Rik, Calcyon, calcyon neuron-specific vesicular protein, DRD1IP, NSG3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Caly often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- binding protein
- transmembrane domain
- D1 dopamine receptor-interacting protein (calcyon)
- clathrin binding
- protein binding
- PDZ binding motif
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Caly gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- agitation
- attention deficit hyperactivity disorder
- pervasive developmental disorder
role in cell
- quantity
- assembly
- recycling
- endocytosis by
- internalization by
- binding in
- movement in
- self-assembly
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- dendritic spine head
- cytoplasmic vesicles
- axons
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Caly gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterograde axon cargo transport
- clathrin coat assembly
- positive regulation of endocytosis
- endosomal transport
- dopamine receptor signaling pathway
- positive regulation of retrograde axon cargo transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- endosome
- membrane
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- clathrin light chain binding
- protein binding