Dctn1 Gene Summary [Mouse]
Enables microtubule binding activity. Acts upstream of or within melanosome transport. Located in cell leading edge and microtubule cytoskeleton. Part of protein-containing complex. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; embryo; and head. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dctn1 |
| Official Name | dynactin 1 [Source:MGI Symbol;Acc:MGI:107745] |
| Ensembl ID | ENSMUSG00000031865 |
| Bio databases IDs | |
| Aliases | dynactin 1 |
| Synonyms | DAP-150, Dctn, DP-150, dynactin 1, DYNACTIN P150, dynactin subunit 1, Glued, HMND14, P135 GLUED, p150, p150-glued |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dctn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- coiled-coil domain
- identical protein binding
- head domain
- Tropomyosin
- Myosin-like coiled-coil protein
- tubulin binding
- basic domain
- SPEC
- Dynein light chain binding domain
- microtubule binding domain
- chromosome segregation protein SMC, primarily archaeal type
- TPR/MLP1/MLP2-like protein
- protein kinase binding
- Hyaluronan mediated motility receptor N-terminal
- CAP-Gly domain
- protein binding
- Dynein associated protein
- Domain of unknown function (DUF4659)
- microtubule binding
- RecF/RecN/SMC N terminal domain
- prefoldin
- Trichohyalin-plectin-homology domain
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- CAP_GLY
Pathways
Biological processes and signaling networks where the Dctn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to amyotrophic lateral sclerosis
- motor neuron disease
- distal hereditary motor neuronopathy type VIIB
- familial motor neuron disease
- amyotrophic lateral sclerosis
- refractive error
- Charcot-Marie-Tooth disease
- psoriatic arthritis
- sporadic amyotrophic lateral sclerosis
- Perry syndrome
role in cell
- binding
- binding in
- cell death
- apoptosis
- formation
- formation in
- lysis
- disassembly
- breakdown
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- soluble fraction
- membrane fraction
- mother centriole
- microtubule cytoskeleton
- spindle apparatus
- cilia
- perinuclear region
- cell cortex
- basal bodies
- vesicles
- centrosome
- centriole
- microtubules
- microtubule bundles
- microtubule tips
- cytoplasmic bridges
- cytosol
- spindle pole
- spindle fibers
- nuclear envelope
- growth cone
- neurites
- intercalated disks
- cytoplasmic vesicles
- plus end of microtubule
- cell membrane leading edge
- mitotic spindle
- kinetochores
- perikaryon
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dctn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventral spinal cord development
- neuromuscular process
- nuclear migration
- nervous system development
- positive regulation of microtubule nucleation
- retrograde transport, endosome to Golgi
- regulation of mitotic spindle organization
- nuclear envelope disassembly
- mitotic cell cycle
- neuromuscular junction development
- cell division
- establishment of mitotic spindle orientation
- neuron homeostasis
- centriole-centriole cohesion
- microtubule anchoring at centrosome
- positive regulation of microtubule polymerization
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell leading edge
- microtubule plus end
- cilium basal body
- spindle pole
- neuronal cell body
- kinetochore
- neuron projection
- microtubule associated complex
- microtubule
- nuclear envelope
- centrosome
- intercellular bridge
- mitotic spindle
- cytoplasm
- centriole
- cell cortex
- membrane
- retromer complex
- spindle
- dynein complex
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- tubulin binding
- protein binding
- tau protein binding
- microtubule binding