Tspan4 Gene Summary [Mouse]
Predicted to enable antigen binding activity and integrin binding activity. Acts upstream of or within mitocytosis and regulation of mitochondrial membrane potential. Located in migrasome. Is expressed in several structures, including gut; jaw; rib cage; urinary system; and viscerocranium. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan4 |
| Official Name | tetraspanin 4 [Source:MGI Symbol;Acc:MGI:1928097] |
| Ensembl ID | ENSMUSG00000025511 |
| Bio databases IDs | |
| Aliases | tetraspanin 4 |
| Synonyms | D130042I01RIK, LOC100911766, NAG-2, Peroxisomal membrane, TETRASPAN, tetraspanin 4, TM4SF7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- integrin binding
- antigen binding
- protein binding
- Tetraspanin family
Pathways
Biological processes and signaling networks where the Tspan4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- venous thromboembolism
- open-angle glaucoma
- postural instability
- serous ovarian adenocarcinoma
- serous ovarian cancer
- Waldenström macroglobulinemia
regulates
- protein-protein complex
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- antigen binding
- integrin binding