Catsper1 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; fusion of sperm to egg plasma membrane involved in single fertilization; and regulation of cilium beat frequency involved in ciliary motility. Located in plasma membrane and sperm principal piece. Part of CatSper complex. Is expressed in germ cell of testis; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 7. Orthologous to human CATSPER1 (cation channel sperm associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Catsper1 |
| Official Name | cation channel, sperm associated 1 [Source:MGI Symbol;Acc:MGI:2179947] |
| Ensembl ID | ENSMUSG00000038498 |
| Bio databases IDs | |
| Aliases | cation channel, sperm associated 1 |
| Synonyms | cation channel sperm associated 1, cation channel, sperm associated 1, CATSPER, KSper, LOC684347, SPGF7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Catsper1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Ion transport protein
- 7TM diverse intracellular signalling
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Catsper1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Calcium Signaling
- CCR5 Signaling in Macrophages
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Mitochondrial Dysfunction
- Netrin Signaling
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Cardiac Hypertrophy
- Sperm Motility
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 7
- asthenozoospermia
regulated by
- progesterone
role in cell
- motility
- function
- hyperpolarization
- hyperpolarization in
- fertilization
- cell movement
- mobility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Catsper1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatogenesis
- regulation of cilium beat frequency involved in ciliary motility
- calcium ion transport
- calcium ion transmembrane transport
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- sperm principal piece
- sperm flagellum
- CatSper complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- protein binding
- voltage-gated calcium channel activity