Plag1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; positive regulation of gene expression; and positive regulation of glial cell proliferation. Acts upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plag1 |
| Official Name | pleiomorphic adenoma gene 1 [Source:MGI Symbol;Acc:MGI:1891916] |
| Ensembl ID | ENSMUSG00000003282 |
| Bio databases IDs | |
| Aliases | pleiomorphic adenoma gene 1 |
| Synonyms | PLAG1 zinc finger, pleiomorphic adenoma gene 1, PSA, SGPA, SRS4, ZNF912 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plag1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- nuclear localization sequence
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- adenoma formation
- soft tissue sarcoma cancer
- Russell-Silver syndrome
- hereditary disorder
- mental retardation
- gastrointestinal neoplasia
- Silver-Russell syndrome type 4
- mature T-cell neoplasia
role in cell
- proliferation
- growth
- contact growth inhibition
- expansion
- G1/S phase transition
- transcription in
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plag1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- negative regulation of gene expression
- positive regulation of gene expression
- positive regulation of glial cell proliferation
- regulation of transcription, DNA-dependent
- gland morphogenesis
- prostate gland growth
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity