Sgpl1 Gene Summary [Mouse]
Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including face morphogenesis; gonad development; and steroid metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgpl1 |
| Official Name | sphingosine phosphate lyase 1 [Source:MGI Symbol;Acc:MGI:1261415] |
| Ensembl ID | ENSMUSG00000020097 |
| Bio databases IDs | |
| Aliases | sphingosine phosphate lyase 1 |
| Synonyms | D10Xrf456, NPHS14, RENI, S1PL, S1P LYASE, SPGL1, sphingosine-1-phosphate lyase, sphingosine-1-phosphate lyase 1, sphingosine phosphate lyase 1, SPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgpl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aminotransferase class-V
- sphinganine-1-phosphate aldolase
- AAT_I
- enzyme
- protein binding
- tyrosine decarboxylase MnfA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung neuroendocrine carcinoma
- lung carcinoma process
- neuroendocrine lung cancer
- neuroendocrine neoplasm
- neoplasia
- nephrotic syndrome type 14
- hereditary disorder
- experimental autoimmune encephalomyelitis
- nephrosis
phenotypes
- abnormal embryo size
- abnormal eye morphology
- preweaning lethality complete penetrance
- Leydig cell hypoplasia
- abnormal T cell physiology
- abnormal blood vessel morphology
- abnormal bone marrow morphology
- abnormal cell migration
- abnormal definitive hematopoiesis
- abnormal frontal bone morphology
- abnormal heart morphology
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal kidney morphology
- abnormal kidney physiology
- abnormal leukocyte migration
- abnormal lipid homeostasis
- abnormal lymph node morphology
- abnormal lymphopoiesis
- abnormal myocardial fiber morphology
- abnormal neurocranium morphology
- abnormal osteoclast morphology
- abnormal ovary morphology
- abnormal palatal shelf fusion at midline
- abnormal postnatal growth
- abnormal pulmonary alveolus morphology
- abnormal renal glomerulus morphology
- abnormal renal/urinary system morphology
- abnormal skeleton morphology
- abnormal small intestine morphology
- abnormal smooth muscle morphology
- abnormal spermatid morphology
- abnormal spermatocyte morphology
- abnormal spermatogenesis
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal sternum morphology
- abnormal testis cord formation
- abnormal testis morphology
- abnormal testosterone level
- abnormal thymus lobule morphology
- abnormal trabecular bone morphology
- abnormal urinary bladder urothelium morphology
- abnormal urothelium morphology
- abnormal vascular smooth muscle morphology
- abnormal vertebrae morphology
- abnormal vertebral arch morphology
- absent corpus luteum
- absent podocyte slit diaphragm
- anemia
- anovulation
- asymmetric sternocostal joints
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased T cell number
- decreased body weight
- decreased circulating estradiol level
- decreased circulating serum albumin level
- decreased circulating testosterone level
- decreased double-positive T cell number
- decreased erythrocyte cell number
- decreased fibroblast cell migration
- decreased hematocrit
- decreased hemoglobin content
- decreased lymphocyte cell number
- decreased neutrophil cell number
- decreased palatine bone horizontal plate size
- decreased pre-B cell number
- decreased secondary ovarian follicle number
- decreased theca cell number
- enlarged heart
- female infertility
- hemorrhage
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased blood urea nitrogen level
- increased granulocyte number
- increased monocyte cell number
- increased osteoclast cell number
- increased single-positive T cell number
- increased vertical activity
- kidney inflammation
- lymph node hypoplasia
- lymphoid hypoplasia
- male infertility
- multinucleated giant male germ cells
- no abnormal phenotype detected
- pale kidney
- podocyte foot process effacement
- polychromatophilia
- postnatal growth retardation
- postnatal lethality
- premature death
- reticulocytosis
- small kidney
- small ovary
- small presphenoid bone
- small testis
- spleen hypoplasia
- thick pulmonary interalveolar septum
- thymus cortex hypoplasia
- thymus hypoplasia
- thymus medulla hyperplasia
- uterus hypoplasia
role in cell
- phosphorylation in
- cell death
- production in
- expression in
- apoptosis
- cell viability
- formation
- degradation in
- growth
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgpl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- estrogen metabolic process
- spermatogenesis
- hemopoiesis
- palate development
- post-embryonic development
- platelet-derived growth factor receptor signaling pathway
- apoptotic signaling pathway
- vasculogenesis
- ceramide metabolic process
- skeletal system morphogenesis
- face morphogenesis
- fatty acid metabolic process
- luteinization
- androgen metabolic process
- kidney development
- fibroblast migration
- Leydig cell differentiation
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- sphinganine-1-phosphate aldolase activity