Muc2 Gene Summary [Mouse]
An extracellular matrix structural constituent. Involved in host-mediated regulation of intestinal microbiota composition; maintenance of gastrointestinal epithelium; and mucus secretion. Acts upstream of or within several processes, including epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is active in mucus layer. Is expressed in hindgut epithelium and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Muc2 |
| Official Name | mucin 2 [Source:MGI Symbol;Acc:MGI:1339364] |
| Ensembl ID | ENSMUSG00000025515 |
| Bio databases IDs | |
| Aliases | mucin 2 |
| Synonyms | 2010015E03Rik, AABR07006030.1, AEKR01108343.1, HH-Muc, LOC100039649, LOC100294420, LOC100862174, LOC682800, LOC682824, MCM, MLP, mucin 2, mucin 2, oligomeric mucus/gel-forming, SMUC, wnn |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Glycoprotein hormone beta chain homologues
- Trypsin Inhibitor like cysteine rich domain
- von Willebrand factor type C domain
- trypsin inhibitor-like cysteine rich domain
- Mucin-2 protein WxxW repeating region
- von Willebrand factor type D domain
- extracellular matrix structural constituent
- protein binding
- von Willebrand factor (vWF) type D domain
- C8 domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- bleeding
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- benign neoplasia
- colon adenocarcinoma
regulated by
- ST6GALNAC1
- cyclosporin A
- tretinoin
- lipopolysaccharide
- NS-398
- nontypeable Haemophilus influenzae strain 12
- SP1
- NFATC3
- trinitrobenzenesulfonic acid
- Il22/Il22b
role in cell
- migration
- apoptosis
- expression in
- proliferation
- differentiation
- motility
- maturation
- function
- abnormal morphology
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Plasma Membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detoxification of copper ion
- homeostasis of number of cells in a free-living population
- mucus secretion
- maintenance of gastrointestinal epithelium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- inner mucus layer
- Golgi lumen
- outer mucus layer
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding