Polr2d Gene Summary [Mouse]
Predicted to enable translation initiation factor binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in cytosol and nuclear speck. Predicted to be part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; brain; cranium; heart; and respiratory system. Orthologous to human POLR2D (RNA polymerase II subunit D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr2d |
| Official Name | polymerase (RNA) II (DNA directed) polypeptide D [Source:MGI Symbol;Acc:MGI:1916491] |
| Ensembl ID | ENSMUSG00000024258 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) II (DNA directed) polypeptide D |
| Synonyms | 2310002G05Rik, 2610028L19RIK, HSRBP4, HSRPB4, polymerase (RNA) II (DNA directed) polypeptide D, RBP4, RNA polymerase II subunit D, RPB16, RPB4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed RNA-polymerase II subunit
- DNA-directed RNA polymerase
- RNA polymerase Rpb4
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Polr2d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- DNA-directed RNA polymerase II, core complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding
- translation initiation factor binding