Polr3b Gene Summary [Mouse]
Predicted to enable DNA/RNA hybrid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and snRNA transcription by RNA polymerase III. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr3b |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide B [Source:MGI Symbol;Acc:MGI:1917678] |
| Ensembl ID | ENSMUSG00000034453 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide B |
| Synonyms | 2700078H01RIK, A330032P03RIK, C128, C85372, CMT1I, HLD8, INMAP, polymerase (RNA) III (DNA directed) polypeptide B, RGD1565311, RNA polymerase III subunit B, RPC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- DNA-directed RNA polymerase
- nucleic acid binding
- RNA_pol_B_RPB2
- enzyme
- RNA polymerase beta subunit
- RNA polymerase Rpb2, domain 4
- RNA polymerase Rpb2, domain 5
- RNA polymerase Rpb2, domain 6
- zinc ion binding
- RNA polymerase Rpb2, domain 3
- RNA polymerase Rpb2, domain 2
- DNA-directed RNA polymerase subunit B
- RNA polymerase Rpb2, domain 7
- DNA-directed RNA polymerase, beta subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- hereditary disorder
- hypomyelinating leukodystrophy type 8
- hypomyelinating leukodystrophy type 8 without hypodontia and with hypogonadotropic hypogonadism
- hypomyelinating leukodystrophy type 8 with hypodontia and hypogonadotropic hypogonadism
- demyelinating Charcot-Marie-Tooth disease type 1I
- hypomyelinating leukodystrophy type 8 without hypodontia or hypogonadotropic hypogonadism
- central nervous system cancer
- POLR3-related leukodystrophy
- glioblastoma
regulates
- IFN beta
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- positive regulation of interferon-beta production
- innate immune response
- defense response to virus
- snRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase III activity
- zinc ion binding
- DNA-directed RNA polymerase activity
- ribonucleoside binding
- DNA/RNA hybrid binding