Polr3d Gene Summary [Mouse]

Enables chromatin binding activity. Predicted to be involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and tRNA transcription by RNA polymerase III. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including 1st branchial arch; limb; nervous system; respiratory system; and sensory organ. Orthologous to human POLR3D (RNA polymerase III subunit D). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Polr3d
Official Name
polymerase (RNA) III (DNA directed) polypeptide D [Source:MGI Symbol;Acc:MGI:1914315]
Ensembl ID
ENSMUSG00000000776
Bio databases IDs NCBI: 67065 Ensembl: ENSMUSG00000000776
Aliases polymerase (RNA) III (DNA directed) polypeptide D
Synonyms 2810426M17Rik, BN51, BN51T, C53, polymerase (RNA) III (DNA directed) polypeptide D, RNA polymerase III subunit D, RPC4, RPC53, TSBN51
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • DNA-directed RNA polymerase
  • chromatin binding
  • RNA polymerase III RPC4

Pathways

Biological processes and signaling networks where the Polr3d gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
regulates
  • IFN beta
  • 5S
  • RN7SL1
  • U6
role in cell
  • expression in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3d gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of innate immune response
  • innate immune response
  • positive regulation of interferon-beta production
  • defense response to virus
  • tRNA transcription from RNA polymerase III promoter

Cellular Component

Where in the cell the gene product is active
  • cytosol
  • DNA-directed RNA polymerase III complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • DNA binding
  • chromatin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.