Hprt Gene Summary [Mouse]
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Hprt |
| Official Name | hypoxanthine guanine phosphoribosyl transferase [Source:MGI Symbol;Acc:MGI:96217] |
| Ensembl ID | ENSMUSG00000025630 |
| Bio databases IDs | |
| Aliases | hypoxanthine guanine phosphoribosyl transferase |
| Synonyms | C81579, HGPRT, Hgprtase, HPGRT, HPRT, Hypoxanthine Phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase 1, LOC103689983 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hprt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hypoxanthine phosphoribosyltransferase
- pentosyltransferase
- Phosphoribosyl transferase domain
- polyglutamine repeat
- glutamine repeat domain
- Phosphoribosyl transferase (PRT)-type I domain
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- lung cancer
- motor dysfunction
- Philadelphia-like B-cell acute lymphoblastic leukemia
- acute lymphoblastic lymphoma
- Lesch-Nyhan syndrome
- graft rejection
- ulcerative colitis
- high-risk acute lymphocytic leukemia
phenotypes
- abnormal gait
- decreased CD4-positive alpha beta T cell number
- decreased circulating total protein level
- decreased erythrocyte cell number
- decreased hemoglobin content
- increased mean corpuscular volume
- abnormal Paneth cell morphology
- abnormal autophagy
- abnormal brain morphology
- abnormal branching of the mammary ductal tree
- abnormal cardiac muscle relaxation
- abnormal ceramide level
- abnormal definitive hematopoiesis
- abnormal depression-related behavior
- abnormal dopaminergic neuron morphology
- abnormal enterocyte apoptosis
- abnormal enterocyte proliferation
- abnormal habituation to a new environment
- abnormal hematopoietic system morphology/development
- abnormal hematopoietic system physiology
- abnormal hippocampus morphology
- abnormal hippocampus physiology
- abnormal liver morphology
- abnormal locomotor activation
- abnormal lung morphology
- abnormal megakaryocyte progenitor cell morphology
- abnormal mitochondrial crista morphology
- abnormal mitochondrial physiology
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal myocardial fiber physiology
- abnormal nervous system morphology
- abnormal neuron differentiation
- abnormal neuronal precursor proliferation
- abnormal nitric oxide homeostasis
- abnormal pancreatic beta cell physiology
- abnormal pancreatic islet morphology
- abnormal physiological response to xenobiotic
- abnormal podocyte morphology
- abnormal podocyte slit diaphragm morphology
- abnormal reflex
- abnormal skeletal muscle fiber morphology
- abnormal sleep pattern
- abnormal small intestine morphology
- abnormal spatial reference memory
- abnormal spatial working memory
- abnormal spleen white pulp morphology
- abnormal splenic cell ratio
- abnormal vascular endothelial cell migration
- abnormal vascular endothelial cell physiology
- abnormal vascular wound healing
- absent podocyte slit diaphragm
- albuminuria
- anemia
- astrocytosis
- ataxia
- cardiac hypertrophy
- convulsive seizures
- decreased B cell number
- decreased anxiety-related response
- decreased body weight
- decreased brain choline acetyltransferase activity
- decreased brain tyrosine 3-monooxygenase activity
- decreased cardiac muscle contractility
- decreased dopamine level
- decreased exploration in new environment
- decreased grip strength
- decreased hematocrit
- decreased insulin secretion
- decreased mean corpuscular hemoglobin concentration
- decreased pancreatic beta cell mass
- decreased pancreatic beta cell number
- decreased susceptibility to injury
- decreased tumor growth/size
- decreased vascular endothelial cell proliferation
- decreased ventricle muscle contractility
- decreased vertical activity
- enlarged lymph nodes
- enlarged spleen
- expanded mesangial matrix
- glomerulosclerosis
- hepatic steatosis
- hyperglycemia
- hypoactivity
- impaired autophagy
- impaired coordination
- impaired social transmission of food preference
- impaired spatial learning
- increased body weight
- increased brain glycogen level
- increased grooming behavior
- increased heart weight
- increased insulin secretion
- increased leukocyte cell number
- increased mammary adenocarcinoma incidence
- increased mammary gland tumor incidence
- increased megakaryocyte cell number
- increased neutrophil cell number
- increased pancreatic beta cell mass
- increased systemic arterial blood pressure
- increased urine protein level
- increased vasoconstriction
- jerky movement
- ketoacidosis
- kyphosis
- limb grasping
- mesangial cell hyperplasia
- myeloid hyperplasia
- neurodegeneration
- neuronal intranuclear inclusions
- no abnormal phenotype detected
- paresis
- phenotypic reversion
- podocyte foot process effacement
- polydipsia
- polyuria
- premature death
- seizures
- short stride length
- skeletal muscle fiber degeneration
- spleen hyperplasia
- testicular atrophy
- thrombocytosis
- tremors
- weight loss
role in cell
- quantity
- proliferation
- cell death
- expression in
- activation in
- differentiation
- phosphorylation in
- development
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hprt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine metabolic process
- purine nucleotide biosynthetic process
- hypoxanthine salvage
- purine ribonucleoside salvage
- GMP catabolic process
- striatum development
- central nervous system neuron development
- positive regulation of dopamine metabolic process
- cerebral cortex neuron differentiation
- dendrite morphogenesis
- IMP metabolic process
- grooming behavior
- locomotory behavior
- protein homotetramerization
- hypoxanthine metabolic process
- adenine metabolic process
- AMP salvage
- GMP salvage
- IMP salvage
- guanine salvage
- response to amphetamine
- lymphocyte proliferation
- dopaminergic neuron differentiation
- T cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleotide binding
- identical protein binding
- protein binding
- guanine phosphoribosyltransferase activity
- hypoxanthine phosphoribosyltransferase activity