Picalm Gene Summary [Mouse]
Predicted to enable several functions, including SH3 domain binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including amyloid-beta clearance by transcytosis; neuron projection morphogenesis; and positive regulation of amyloid-beta formation. Located in clathrin-coated pit and vesicle. Colocalizes with perinuclear region of cytoplasm. Is expressed in several structures, including aorta; brain; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Picalm |
| Official Name | phosphatidylinositol binding clathrin assembly protein [Source:MGI Symbol;Acc:MGI:2385902] |
| Ensembl ID | ENSMUSG00000039361 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol binding clathrin assembly protein |
| Synonyms | AP180, CALM, clathrin assembly lymphoid myeloid leukaemia, CLTH, fit-1, LAP, mKIAA4114, PAP180, PCALM, phosphatidylinositol binding clathrin assembly protein, SEP6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Picalm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- clathrin binding domain
- enzyme binding
- clathrin binding
- protein binding
- low-density lipoprotein receptor binding
- Clathrin HC binding domain
- identical protein binding
- SH3-domain binding
- phosphatidylinositol binding
- tau protein binding
- phosphatidylinositol-4,5-bisphosphate binding
- VHS, ENTH and ANTH domain superfamily
Pathways
Biological processes and signaling networks where the Picalm gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ischemic stroke
- late-onset Alzheimer disease
- acute myeloid leukemia
- Alzheimer disease
- growth failure
- hemosiderosis
- tumorigenesis
- insomnia
- microcytic anemia
role in cell
- accumulation in
- phosphorylation in
- proliferation
- production in
- invasion
- formation
- differentiation
- number
- transport
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- exocytic vesicle
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- cytosol
- presynaptic membrane
- postsynaptic membrane
- trans Golgi network
- synaptic vesicles
- growth cone
- nerve ending
- synapse
- early endosomes
- clathrin-coated pits
- membrane processes
- perikaryon
- postsynaptic density
- excitatory synapses
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Picalm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- hemopoiesis
- positive regulation of Ras protein signal transduction
- dendrite morphogenesis
- learning or memory
- cellular iron ion homeostasis
- clathrin-mediated endocytosis
- vesicle-mediated transport
- positive regulation of transcription, DNA-dependent
- clathrin coat assembly
- axonogenesis
- cargo loading into vesicle
- endosomal transport
- regulation of endocytosis
- negative regulation of receptor-mediated endocytosis
- macromolecular complex assembly
- regulation of protein localization
- endocytosis
- receptor-mediated endocytosis
- negative regulation of gene expression
- negative regulation of protein localization at cell surface
- membrane budding
- synaptic vesicle budding from presynaptic membrane
- synaptic vesicle maturation
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synaptic vesicle
- Golgi apparatus
- clathrin-coated endocytic vesicle
- neuronal cell body
- plasma membrane
- cell surface
- nucleus
- early endosome
- endosome to plasma membrane transport vesicle
- perinuclear region of cytoplasm
- postsynaptic membrane
- coated pit
- intracellular membrane-bounded organelle
- membrane
- clathrin coat of coated pit
- vesicle
- cytosol
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- phosphatidylinositol-4,5-bisphosphate binding
- low-density lipoprotein particle receptor binding
- protein binding
- cadherin binding
- tau protein binding
- small GTPase binding
- clathrin binding
- SNARE binding
- beta-amyloid binding
- 1-phosphatidylinositol binding