Pygm Gene Summary [Mouse]
This gene encodes a glycolysis enzyme found in muscle. Highly similar enzymes encoded by different genes are found in liver and brain. The encoded protein is involved in regulating the breakdown of glycogen to glucose-1-phosphate, which is necessary for ATP generation. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Pygm |
| Official Name | muscle glycogen phosphorylase [Source:MGI Symbol;Acc:MGI:97830] |
| Ensembl ID | ENSMUSG00000032648 |
| Bio databases IDs | |
| Aliases | muscle glycogen phosphorylase |
| Synonyms | glycogen phosphorylase, muscle associated, GP, GSD5, M-GP, Muscle glycogen phosphorylase, Muscpho, myophosphorylase, PG, PHOS A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pygm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- pyridoxal phosphate binding
- AMP binding
- Carbohydrate phosphorylase
- glycogen/starch/alpha-glucan phosphorylases
- enzyme
- protein binding
- carbohydrate binding
- phosphorylase
- glycogen phosphorylase
Pathways
Biological processes and signaling networks where the Pygm gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- glycogen storage disease V
- androgenic alopecia
- glycogen storage disease
- rhabdomyolysis
regulates
- Ca2+
- MBP
- glycogen
- glycogen synthase
role in cell
- proliferation
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- sarcoplasmic reticulum
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pygm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen metabolic process
- glycogen catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- glycogen phosphorylase activity
- pyridoxal phosphate binding
- protein binding