Rdh11 Gene Summary [Mouse]
Enables aldehyde dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde; retinol metabolic process; and visual perception. Located in photoreceptor inner segment. Is expressed in eye and forebrain. Orthologous to human RDH11 (retinol dehydrogenase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdh11 |
| Official Name | retinol dehydrogenase 11 [Source:MGI Symbol;Acc:MGI:102581] |
| Ensembl ID | ENSMUSG00000066441 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 11 |
| Synonyms | 2610319N22Rik, Androgen-regulated short-chain dehydrogenase/reductase 1, ARSDR1, CGI-82, HCBP12, M42C60, MDT1, PSDR1, RALR1, RDJCSS, retinol dehydrogenase 11, SCALD, SDR7C1, Ube-1c, UBE-1c1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- aldehyde dehydrogenase [NAD(P)]
- CH-OH group:NAD or NADP oxidoreductase
- retinol dehydrogenase
- enzyme
- protein binding
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Rdh11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- retinal dystrophy, juvenile cataracts, and short stature syndrome
- silicosis
regulates
- 11-cis-retinyl esters
- retinoid
- 11/13-cis-retinyl ester
- retinol
- NR3C1
- retinaldehyde
- 13-cis-retinyl esters
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoid metabolic process
- retinol metabolic process
- retinal metabolic process
- visual perception
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinol dehydrogenase activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- NADP-retinol dehydrogenase activity
- aldehyde dehydrogenase (NADP+) activity