Gab2 Gene Summary [Mouse]
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of epithelial cell migration; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Located in membrane raft. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to several human genes including GAB2 (GRB2 associated binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gab2 |
| Official Name | growth factor receptor bound protein 2-associated protein 2 [Source:MGI Symbol;Acc:MGI:1333854] |
| Ensembl ID | ENSMUSG00000004508 |
| Bio databases IDs | |
| Aliases | growth factor receptor bound protein 2-associated protein 2 |
| Synonyms | AI463667, D130058I17Rik, GRB2-associated binding protein 2, growth factor receptor bound protein 2-associated protein 2, p97, p98 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Met binding domain
- PI3K binding domain
- protein phosphatase binding
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
- Grb2 binding domain
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- PH domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- SHP-2 binding domain
Pathways
Biological processes and signaling networks where the Gab2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- tumorigenesis
- organismal death
role in cell
- expression in
- differentiation
- phosphorylation in
- invasion by
- proliferation
- migration
- survival
- activation in
- apoptosis
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- abaxonal cytoplasm
- Plasma Membrane
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- positive regulation of mast cell degranulation
- protein kinase B signaling cascade
- signal transduction
- positive regulation of cell proliferation
- transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane raft
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- phosphatidylinositol-3,4-bisphosphate binding