Slc25a10 Gene Summary [Rat]
Enables malate transmembrane transporter activity and phosphate transmembrane transporter activity. Involved in malate transport and phosphate ion transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a10 |
| Official Name | solute carrier family 25 member 10 [Source:RGD Symbol;Acc:621430] |
| Ensembl ID | ENSRNOG00000036693 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 10 |
| Synonyms | DIC, Dicarboxylate carrier, MTDPS19, solute carrier family 25 member 10, solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc25a10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thiosulfate transporter
- inorganic phosphate transporter
- porter
- sulfate transporter
- Mitochondrial carrier protein
- malate transporter
- dicarboxylic acid transporter
- antiporter
- protein binding
- succinate transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc25a10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial DNA depletion syndrome 19
- Mitochondrial complex I deficiency
- lung adenocarcinoma
- lung adenocarcinoma formation
- mitochondrial disorder
- insulin resistance
- dental caries
role in cell
- apoptosis
- accumulation
- insulin sensitivity
- transport
- gluconeogenesis in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc25a10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfate transport
- gluconeogenesis
- dicarboxylic acid transport
- lipid transport
- ion transport
- sulfide oxidation, using sulfide:quinone oxidoreductase
- thiosulfate transport
- glyceraldehyde-3-phosphate biosynthetic process
- oxaloacetate transport
- succinate transmembrane transport
- malate transmembrane transport
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- antiporter activity
- oxaloacetate transmembrane transporter activity
- succinate transmembrane transporter activity
- malate transmembrane transporter activity
- dicarboxylic acid transmembrane transporter activity
- thiosulfate transmembrane transporter activity
- sulfate transmembrane transporter activity