Pard3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein phosphatase binding activity. Involved in several processes, including negative regulation of peptidyl-threonine phosphorylation; positive regulation of myelination; and positive regulation of receptor internalization. Acts upstream of or within several processes, including apical constriction; centrosome localization; and wound healing, spreading of cells. Located in several cellular components, including Schmidt-Lanterman incisure; internode region of axon; and lateral loop. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pard3 |
| Official Name | par-3 family cell polarity regulator [Source:MGI Symbol;Acc:MGI:2135608] |
| Ensembl ID | ENSMUSG00000025812 |
| Bio databases IDs | |
| Aliases | par-3 family cell polarity regulator |
| Synonyms | ASIP, atypical pkc-specific binding, Baz, circPard3, D8Ertd580e, MPAR3, PAR3, PAR3A, PAR3alpha, par-3 family cell polarity regulator, PARD3A, Phip, PPP1R118, SE2-5, SE2-5L16, SE2-5LT1, SE2-5T2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pard3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- activation domain
- protein phosphatase binding
- CR1 domain
- canonical PDZ domain
- aPKC binding domain
- coiled-coil domain
- protein binding
- PDZ domain
- identical protein binding
- N-terminal of Par3 and HAL proteins
- phosphatidylinositol binding
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- cpPDZ_Deg_HtrA-like
- PDZ binding motif
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Pard3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- benign neoplasia
- cancer
- papillomatosis
- neural tube defect
- metastasis
- edema
- growth failure
- prostate cancer
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- proliferation
- migration
- number
- synthesis in
- production in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- low-density microsomal fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell junction
- axon component
- spindle apparatus
- Cytoplasm
- cell periphery
- cellular membrane
- Nucleus
- microtubules
- microtubule tips
- intercellular junctions
- cell-cell contacts
- cytosol
- primary cilia
- acrosome
- growth cone
- paranodal loops
- neurites
- paranodes
- nerve ending
- myelin sheath
- synaptosomes
- Schmidt-Lanterman incisures
- anchoring junction
- tight junctions
- junctional complexes
- apical cell-cell contacts
- perikaryon
- axons
- axonal shafts
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pard3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- establishment or maintenance of cell polarity
- protein localization
- asymmetric cell division
- cell adhesion
- establishment of epithelial cell polarity
- microtubule cytoskeleton organization
- protein kinase C-activating G-protein coupled receptor signaling pathway
- protein targeting to membrane
- myelination in peripheral nervous system
- establishment of centrosome localization
- negative regulation of peptidyl-threonine phosphorylation
- establishment or maintenance of epithelial cell apical/basal polarity
- axonogenesis
- tight junction assembly
- establishment of cell polarity
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- adherens junction
- tight junction
- occluding junction
- cytoskeleton
- cell-cell junction
- cell cortex
- apical junction complex
- internode region of axon
- cytosol
- endomembrane system
- cell junction
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol binding
- phosphatidylinositol-3-phosphate binding