Stradb Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activator activity. Acts upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Predicted to be part of serine/threonine protein kinase complex. Is expressed in central nervous system; liver; and retina. Orthologous to human STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Stradb |
| Official Name | STE20-related kinase adaptor beta [Source:MGI Symbol;Acc:MGI:2144047] |
| Ensembl ID | ENSMUSG00000026027 |
| Bio databases IDs | |
| Aliases | STE20-related kinase adaptor beta |
| Synonyms | ALS2CR2, B830008M19, CALS-21, D1Ucla2, ILPIP, ILPIPA, PAPK, PRO1038, RGD1559449, STE20 related adaptor beta, STE20 related adaptor β, STE20-related kinase adaptor beta, STE20-related kinase adaptor β, STRAD beta, STRAD β, Syradb |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stradb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- perinuclear region
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stradb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- cell morphogenesis
- activation of protein kinase activity
- JNK cascade
- protein export from nucleus
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- aggresome
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activator activity
- protein kinase activity