Poglut2 Gene Summary [Mouse]
Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; genitourinary system; gut; liver; and spleen. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Poglut2 |
| Official Name | protein O-glucosyltransferase 2 [Source:MGI Symbol;Acc:MGI:1919300] |
| Ensembl ID | ENSMUSG00000026047 |
| Bio databases IDs | |
| Aliases | protein O-glucosyltransferase 2 |
| Synonyms | 1810049A15Rik, 5730416C13Rik, EP58, ERp58, KDEL1, KDELC1, protein O-glucosyltransferase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Poglut2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Filamin/ABP280 repeat
- Glycosyl transferase family 90
- enzyme
- xylosyltransferase
- UDP-glycosyltransferase
- UDP-glucosyltransferase activity
- Filamin-type immunoglobulin domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma cancer
- cancer
- glioma formation
- melanoma cancer
- epithelial cancer
- epithelial neoplasia
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hepatocellular carcinoma
role in cell
- apoptosis
- proliferation
- migration
- invasion by
- cloning by
- O-glucosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- endoplasmic reticulum lumen
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Poglut2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation via serine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endomembrane system
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- UDP-glucosyltransferase activity
- UDP-xylosyltransferase activity
- glucosyltransferase activity