Golga4 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and positive regulation of axon extension. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Golga4 |
| Official Name | golgi autoantigen, golgin subfamily a, 4 [Source:MGI Symbol;Acc:MGI:1859646] |
| Ensembl ID | ENSMUSG00000038708 |
| Bio databases IDs | |
| Aliases | golgi autoantigen, golgin subfamily a, 4 |
| Synonyms | AC097359.1, CRPF46, GCP2, GOLG, GOLGIN-245, golgin A4, MU-RMS-40.18, Olp-1, p230, TGN230, Trans-Golgi p230 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Golga4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- rad50
- GRIP domain
- enzyme binding
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Protein of unknown function (DUF3584)
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- diabetic retinopathy
- senile lentigo
regulates
- mannosidase 2
- MPR
role in cell
- apoptosis
- proliferation
- extension
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear Golgi regions
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- nucleoplasm
- plasma
- trans Golgi cisternae
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Golga4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- Golgi to plasma membrane protein transport
- positive regulation of axon extension
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi apparatus
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- small GTPase binding