Notch2 Gene Summary [Mouse]
Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including left/right pattern formation; marginal zone B cell differentiation; and nephron development. Acts upstream of or within several processes, including activation of protein kinase B activity; cholangiocyte proliferation; and liver development. Located in cilium; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Notch2 |
| Official Name | notch 2 [Source:MGI Symbol;Acc:MGI:97364] |
| Ensembl ID | ENSMUSG00000027878 |
| Bio databases IDs | |
| Aliases | notch 2 |
| Synonyms | AGS2, AI853703, HJCYS, hN2, N2, Neurogenic locus notch homolog protein 2 precursor, notch receptor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Notch2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- transcription regulator
- Ankyrin repeats (many copies)
- JMTM_Notch_APP
- RAM domain
- Ankyrin repeat
- EGF_CA
- cytoplasmic domain
- intracellular domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- extracellular domain
- nucleic acid binding
- NF-kappaB binding
- ectodomain
- Human growth factor-like EGF
- LNR domain
- negative regulatory domain
- enzyme binding
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- EGF-like domain
- NOTCH protein
- double-stranded DNA binding
- ICN1 domain
- transmembrane domain
Pathways
Biological processes and signaling networks where the Notch2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- neoplasia
- lung cancer
- chronic myelomonocytic leukemia
- pancreatic neoplasia
- cancer
- non-Hodgkin lymphoma
- non-Hodgkin disease
- systemic lupus erythematosus
- sarcomatoid nasopharyngeal carcinoma
role in cell
- formation
- binding
- phosphorylation in
- expression in
- activation
- production in
- activation in
- cell death
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- pH resistant lipid raft fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- cilia
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- synaptic membrane
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Notch2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- hemopoiesis
- nervous system development
- axon guidance
- positive regulation of Ras protein signal transduction
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of keratinocyte proliferation
- embryonic limb morphogenesis
- wound healing
- marginal zone B cell differentiation
- positive regulation of osteoclast differentiation
- inflammatory response to antigenic stimulus
- in utero embryonic development
- BMP signaling pathway
- myeloid dendritic cell differentiation
- humoral immune response
- apoptotic process
- heart looping
- regulation of osteoclast development
- glomerular capillary formation
- cell fate determination
- left/right axis specification
- intracellular signal transduction
- placenta blood vessel development
- bone remodeling
- atrioventricular node development
- pulmonary valve morphogenesis
- morphogenesis of an epithelial sheet
- defense response to bacterium
- atrial septum morphogenesis
- organ morphogenesis
- positive regulation of BMP signaling pathway
- negative regulation of gene expression
- Notch signaling pathway
- glomerular visceral epithelial cell development
- proximal tubule development
- hepatocyte proliferation
- positive regulation of smooth muscle cell differentiation
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- ciliary body morphogenesis
- cellular response to tumor cell
- intrahepatic bile duct development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- cilium
- receptor complex
- Golgi membrane
- extracellular region
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding
- calcium ion binding
- signaling receptor activity
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- enzyme binding