Dnajb2 Gene Summary [Mouse]
Predicted to enable several functions, including Hsp70 protein binding activity; enzyme binding activity; and proteasome binding activity. Predicted to be involved in several processes, including proteasomal protein catabolic process; protein folding; and regulation of protein metabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to human DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajb2 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B2 [Source:MGI Symbol;Acc:MGI:1928739] |
| Ensembl ID | ENSMUSG00000026203 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B2 |
| Synonyms | 2700059H22Rik, CMT2T, DNAJB10, DnaJ heat shock protein family (Hsp40) member B2, Dnaj (Hsp40) Homolog, Subfamily B, Member 10, DSMA5, HDJ1, HMNR5, HSJ-1, HSPF3, LOC681650, mDj8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-interacting motif
- ATPase stimulator
- ubiquitin protein ligase binding
- Hsp70 protein binding
- protein kinase binding
- Ubiquitin interaction motif
- protein binding activity, bridging
- ubiquitin binding
- protein binding
- DnaJ domain
- DnaJ
- DnaJ molecular chaperone homology domain
- binding protein
- chaperone binding
- transporter
Pathways
Biological processes and signaling networks where the Dnajb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- autosomal recessive distal spinal muscular atrophy type 5
- Charcot-Marie-Tooth disease X-linked type 1
- hereditary disorder
- metastatic prostate cancer
- primary prostate cancer
- axonal Charcot-Marie-Tooth disease type 2T
- distal spinal muscular atrophy
- infection by Zaire ebolavirus
- infection by Marburg virus
role in cell
- assembly
- proliferation
- aggregation in
- formation
- growth
- cell death
- aggregation
- homeostasis
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- perinuclear region
- vacuole
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- nuclear envelope
- photoreceptor outer segments
- photoreceptor inner segments
- membrane processes
- clathrin-coated vesicles
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- positive regulation of ATPase activity
- negative regulation of cell growth
- negative regulation of cell proliferation
- chaperone-mediated protein folding
- regulation of protein ubiquitination
- protein refolding
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein binding
- response to unfolded protein
- negative regulation of inclusion body assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- nuclear membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- chaperone binding
- unfolded protein binding
- ATPase activator activity
- Hsp70 protein binding