Arl1 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; GTPase activity; and phospholipase D activator activity. Predicted to be involved in several processes, including Golgi organization; protein localization to Golgi apparatus; and retrograde transport, endosome to Golgi. Located in cytoplasm. Is expressed in genitourinary system and inner ear. Orthologous to human ARL1 (ARF like GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl1 |
| Official Name | ADP-ribosylation factor-like 1 [Source:MGI Symbol;Acc:MGI:99436] |
| Ensembl ID | ENSMUSG00000060904 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 1 |
| Synonyms | 2310008D22Rik, ADP-ribosylation factor-like 1, ARFL1, ARF like GTPase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain-switch II region
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- enzyme activator activity
- phospholipase activator
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- growth
- morphology
- organization
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- trans Golgi network
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- protein localization in Golgi apparatus
- Golgi organization
- retrograde transport, endosome to Golgi
- intracellular protein transport
- toxin metabolic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
- cytosol
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein domain specific binding
- protein binding
- metal ion binding
- GTPase activity
- enzyme activator activity