Acmsd Gene Summary [Mouse]
Predicted to enable aminocarboxymuconate-semialdehyde decarboxylase activity and zinc ion binding activity. Predicted to be involved in L-tryptophan catabolic process; negative regulation of quinolinate biosynthetic process; and secondary metabolic process. Predicted to act upstream of or within quinolinate metabolic process. Predicted to be active in cytosol. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acmsd |
| Official Name | amino carboxymuconate semialdehyde decarboxylase [Source:MGI Symbol;Acc:MGI:2386323] |
| Ensembl ID | ENSMUSG00000026348 |
| Bio databases IDs | |
| Aliases | amino carboxymuconate semialdehyde decarboxylase |
| Synonyms | 2-AMINO-3-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE, alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase, alpha-AMINO-beta-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE, ?-Amino-?-Carboxymuconate-?-Semialdehyde Decarboxylase, amino carboxymuconate semialdehyde decarboxylase, Picolinate carboxylase, α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase, α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acmsd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aminocarboxymuconate-semialdehyde decarboxylase
- zinc ion binding
- enzyme
- protein binding
- metallo-dependent_hydrolases
- amidohydrolase
Pathways
Biological processes and signaling networks where the Acmsd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
regulates
- quinolinic acid
- picolinic acid
- alpha-amino-omega-carboxymuconic acid semialdehyde
- L-tryptophan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acmsd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- secondary metabolic process
- tryptophan catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- aminocarboxymuconate-semialdehyde decarboxylase activity
- hydrolase activity