Gpsm3 Gene Summary [Mouse]
Predicted to enable GTPase regulator activity. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response; positive regulation of inflammatory response; and positive regulation of leukocyte chemotaxis. Located in plasma membrane. Is expressed in genitourinary system; gut; skin; and thymus. Orthologous to human GPSM3 (G protein signaling modulator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpsm3 |
| Official Name | G-protein signalling modulator 3 (AGS3-like, C. elegans) [Source:MGI Symbol;Acc:MGI:2146785] |
| Ensembl ID | ENSMUSG00000034786 |
| Bio databases IDs | |
| Aliases | G-protein signalling modulator 3 (AGS3-like, C. elegans) |
| Synonyms | AA960287, AGS4, C6orf9, G18, G18.1a, G18.1b, G18.2, G-protein signaling modulator 3, G-protein signalling modulator 3 (AGS3-like, C. elegans), NG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpsm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein regulatory motif
- GoLoco motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- pancreatic carcinoma
- pancreatic epithelial cancer
- scarlet fever
- autoimmune disease
- sarcoidosis
role in cell
- production in
- activation in
- inhibition in
- binding in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpsm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of inflammatory response
- positive regulation of leukocyte chemotaxis
- positive regulation of cytokine production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase regulator activity