Cdk20 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic organ development; and negative regulation of smoothened signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in bronchiole; thymus primordium; and trachea. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human CDK20 (cyclin dependent kinase 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk20 |
| Official Name | cyclin-dependent kinase 20 [Source:MGI Symbol;Acc:MGI:2145349] |
| Ensembl ID | ENSMUSG00000021483 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 20 |
| Synonyms | 4932702G04Rik, CCRK, CDCH, cyclin-dependent kinase 20, P42, PNQALRE, PNQLARE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdk20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Cdk20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdk20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- floor plate formation
- neural tube closure
- embryonic camera-type eye development
- palate development
- regulation of cell cycle
- embryonic skeletal system development
- protein phosphorylation
- negative regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity