Ubxn4 Gene Summary [Mouse]
Predicted to be involved in ERAD pathway. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum. Is expressed in embryo. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubxn4 |
| Official Name | UBX domain protein 4 [Source:MGI Symbol;Acc:MGI:1915062] |
| Ensembl ID | ENSMUSG00000026353 |
| Bio databases IDs | |
| Aliases | UBX domain protein 4 |
| Synonyms | 1300013G12Rik, erasin, KIAA0242, mKIAA0242, UBXD2, UBXDC1, UBX domain protein 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubxn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubl1_cv_Nsp3_N-like
- Thioredoxin-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
Pathways
Biological processes and signaling networks where the Ubxn4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- keratoconus
- lung adenocarcinoma
- lung adenocarcinoma formation
- non-small cell lung carcinoma
- non-small cell lung cancer
regulated by
- dithiothreitol
- tunicamycin
- L-glutamic acid
- thapsigargin
- SLC2A5
- n-nitrosomethylbenzylamine
- phenethyl isothiocyanate
- Influenza A virus (A/Japan/305/57(H2N2))
- phycocyanobilin
- calcimycin
regulates
role in cell
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubxn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding