Epb41l5 Gene Summary [Mouse]
Enables protein domain specific binding activity. Involved in epithelial to mesenchymal transition. Acts upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Located in focal adhesion and ruffle membrane. Is expressed in several structures, including foregut; lung; metanephros; neural tube; and primitive streak. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epb41l5 |
| Official Name | erythrocyte membrane protein band 4.1 like 5 [Source:MGI Symbol;Acc:MGI:103006] |
| Ensembl ID | ENSMUSG00000026383 |
| Bio databases IDs | |
| Aliases | erythrocyte membrane protein band 4.1 like 5 |
| Synonyms | 1700030C16RIK, BE37, E230025E14Rik, EPB4.1L5, erythrocyte membrane protein band 4.1 like 5, LULU, LULU1, NBL5, YMO1, YRT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epb41l5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM adjacent (FA)
- FERM central domain
- Band 4.1 homologues
- Ubl1_cv_Nsp3_N-like
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- FERM N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- hepatocellular carcinoma
- epithelial cancer
- organismal death
- chordoma
- bone cancer
- liver cancer
- focal segmental glomerulosclerosis
- glioblastoma
- glioblastoma cancer
role in cell
- migration
- morphology
- growth
- adhesion
- substrate adhesion
- organization
- migration by
- assembly
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- cytosol
- membrane ruffles
- nucleoplasm
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epb41l5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin structure organization
- endoderm development
- negative regulation of cell-cell adhesion
- paraxial mesoderm development
- apical constriction
- ectoderm development
- substrate-dependent cell migration, cell attachment to substrate
- embryonic foregut morphogenesis
- axial mesoderm morphogenesis
- posttranscriptional regulation of gene expression
- cellular response to transforming growth factor beta stimulus
- unidimensional cell growth
- positive regulation of focal adhesion assembly
- in utero embryonic development
- mesoderm migration involved in gastrulation
- epithelial to mesenchymal transition
- regulation of establishment of protein localization
- positive regulation of epithelial cell migration
- neural plate morphogenesis
- somite rostral/caudal axis specification
- left/right axis specification
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- focal adhesion
- cytosol
- ruffle membrane
- photoreceptor inner segment
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- cytoskeletal protein binding