Arl8a Gene Summary [Mouse]
Predicted to enable GTP binding activity. Involved in anterograde axonal transport. Predicted to be located in cytoplasm; midbody; and spindle midzone. Predicted to be active in lysosomal membrane. Is expressed in cortical plate; ganglia; sensory organ; and submandibular gland primordium. Orthologous to human ARL8A (ARF like GTPase 8A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl8a |
| Official Name | ADP-ribosylation factor-like 8A [Source:MGI Symbol;Acc:MGI:1915974] |
| Ensembl ID | ENSMUSG00000026426 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 8A |
| Synonyms | 1110033P22Rik, ADP-ribosylation factor-like 8A, ARF like GTPase 8A, ARL10B, GIE2, RGD1565940 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- GTP binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Ras family
- alpha-tubulin binding
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- midbody
- secretory granule membrane
- lysosome membrane
- synaptic vesicles
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- anterograde axon cargo transport
- protein transport
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- spindle midzone
- extracellular vesicular exosome
- cytoplasm
- membrane
- midbody
- synapse
- azurophil granule membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- beta-tubulin binding
- alpha-tubulin binding