Mixl1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including endodermal cell differentiation; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of mesoderm development. Acts upstream of or within several processes, including digestive tract development; gastrulation; and hemopoiesis. Located in chromatin and nucleus. Is expressed in several structures, including early embryo; egg cylinder; embryo mesoderm; metanephros; and primitive streak. Orthologous to human MIXL1 (Mix paired-like homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mixl1 |
| Official Name | Mix1 homeobox-like 1 (Xenopus laevis) [Source:MGI Symbol;Acc:MGI:1351322] |
| Ensembl ID | ENSMUSG00000026497 |
| Bio databases IDs | |
| Aliases | Mix1 homeobox-like 1 (Xenopus laevis) |
| Synonyms | MILD1, MIX, MIXL, Mix paired-like homeobox, Mix paired-like homeobox 1, Mm1, Mml, NEWGENE 1310011 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mixl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein homodimerization
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- yolk sac neoplasm
- germ cell neoplasia
role in cell
- migration
- differentiation
- transactivation in
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mixl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- cell migration involved in gastrulation
- digestive tract development
- positive regulation of mesoderm development
- endoderm development
- endodermal cell differentiation
- endoderm formation
- positive regulation of transcription from RNA polymerase II promoter
- hemopoietic progenitor cell differentiation
- gastrulation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity