Opn3 Gene Summary [Mouse]
Predicted to enable 11-cis retinal binding activity; G protein-coupled photoreceptor activity; and all-trans retinal binding activity. Involved in positive regulation of D-glucose import; positive regulation of cellular respiration; and response to blue light. Predicted to be located in cytoplasm. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in eye and orbito-sphenoid. Orthologous to human OPN3 (opsin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opn3 |
| Official Name | opsin 3 [Source:MGI Symbol;Acc:MGI:1338022] |
| Ensembl ID | ENSMUSG00000026525 |
| Bio databases IDs | |
| Aliases | opsin 3 |
| Synonyms | ECPN, Encephalopsin, ERO, Opsin, opsin 3, PPP1R116 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Opn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- all-trans retinal binding
- 7 transmembrane receptor (rhodopsin family)
- 11-cis retinal binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Opn3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- survival
- expression in
- apoptosis
- activation in
- differentiation
- quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Opn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- detection of visible light
- detection of light stimulus
- positive regulation of glucose import
- regulation of circadian rhythm
- response to blue light
- phototransduction
- positive regulation of melanin biosynthetic process
- cellular response to light stimulus
- keratinocyte differentiation
- negative regulation of melanin biosynthetic process
- cellular response to UV-A
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- all-trans retinal binding
- 11-cis retinal binding
- G-protein coupled receptor activity
- protein binding
- photoreceptor activity
- G-protein coupled photoreceptor activity