Mc1r Gene Summary [Mouse]
Enables melanocyte-stimulating hormone receptor activity. Involved in several processes, including phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cAMP/PKA signal transduction; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within melanin biosynthetic process; pigmentation; and sensory perception of pain. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; foregut; musculature; sensory organ; and skin. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mc1r |
| Official Name | melanocortin 1 receptor [Source:MGI Symbol;Acc:MGI:99456] |
| Ensembl ID | ENSMUSG00000074037 |
| Bio databases IDs | |
| Aliases | melanocortin 1 receptor |
| Synonyms | CMM5, HCL2, Mcr1, Melanocortin 1 Receptor, MSH-R, Mshra, SHEP2, Tob |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mc1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- ubiquitin protein ligase binding
- hormone binding
- melanocyte stimulating hormone receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- melanocortin receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- loop domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Mc1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- cancer
- acne vulgaris
- skin cancer
- squamous cell cancer
- rosacea
- seborrheic dermatitis
- susceptibility to UV-induced skin damage
- acquired generalized hypoactive sexual desire disorder
role in cell
- apoptosis
- activation in
- phosphorylation in
- expression in
- migration
- accumulation in
- induction in
- cellular infiltration by
- synthesis in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mc1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- melanin biosynthetic process
- UV-damage excision repair
- UV protection
- positive regulation of protein kinase C signaling cascade
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of protein kinase A signaling cascade
- pigmentation
- sensory perception of pain
- regulation of metabolic process
- positive regulation of feeding behavior
- negative regulation of tumor necrosis factor production
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- melanocortin receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- ubiquitin protein ligase binding
- hormone binding
- melanocyte-stimulating hormone receptor activity