Mpc2 Gene Summary [Mouse]
Enables pyruvate transmembrane transporter activity. Involved in pyruvate decarboxylation to acetyl-CoA. Acts upstream of or within mitochondrial pyruvate transmembrane transport and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including brain; early conceptus; heart; and liver. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mpc2 |
| Official Name | mitochondrial pyruvate carrier 2 [Source:MGI Symbol;Acc:MGI:1917706] |
| Ensembl ID | ENSMUSG00000026568 |
| Bio databases IDs | |
| Aliases | mitochondrial pyruvate carrier 2 |
| Synonyms | 0-44 Protein Homolog, 0610006C01Rik, 2010002I07RIK, 2610205H19Rik, BRP44, ESTM43, mitochondrial pyruvate carrier 2, RGD1563422, SLC54A2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitochondrial pyruvate carriers
- protein binding
- monocarboxylic acid transporter
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- acute myeloid leukemia
- schizophrenia
regulates
- insulin
- pyruvic acid
- oxygen
role in cell
- consumption in
- metabolism in
- mitochondrial respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process from pyruvate
- mitochondrial pyruvate transport
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- pyruvate transmembrane transporter activity