Eif3f Gene Summary [Mouse]
Enables cysteine-type deubiquitinase activity and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif3f |
| Official Name | eukaryotic translation initiation factor 3, subunit F [Source:MGI Symbol;Acc:MGI:1913335] |
| Ensembl ID | ENSMUSG00000031029 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3, subunit F |
| Synonyms | 0610037M02Rik, eIF3-p47, EIF3S5, Eif3-ε, eukaryotic translation initiation factor 3 subunit F, eukaryotic translation initiation factor 3, subunit F, MRT67 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif3f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- Mpr1p, Pad1p N-terminal (MPN) domains
- ubiquitin-specific protease
- translation initiation factor
- protein binding
- Maintenance of mitochondrial structure and function
- identical protein binding
- translation regulator
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Eif3f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- breast cancer
- melanoma cancer
- hereditary disorder
- autosomal recessive intellectual developmental disorder type 67
- ovarian cancer
- ovarian neoplasm
- ovarian neoplasia
- neurodevelopmental disorder
role in cell
- expression in
- proliferation
- cell viability
- cell death
- growth
- activation in
- apoptosis
- colony formation by
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- multicilium
- Nucleus
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif3f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- proteolysis
- translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 3 complex, eIF3m
- eukaryotic 43S preinitiation complex
- membrane
- cytosol
- synapse
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- translation initiation factor activity
- identical protein binding
- protein binding
- translation initiation factor binding