Suv39h2 Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone H3K9me2 methyltransferase activity. Involved in circadian rhythm; male meiotic nuclear division; and negative regulation of macromolecule biosynthetic process. Located in heterochromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and limb. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suv39h2 |
| Official Name | suppressor of variegation 3-9 2 [Source:MGI Symbol;Acc:MGI:1890396] |
| Ensembl ID | ENSMUSG00000026646 |
| Bio databases IDs | |
| Aliases | suppressor of variegation 3-9 2 |
| Synonyms | 4930507K23Rik, D030054H19RIK, D2Ertd544e, KMT1B, suppressor of variegation 3-9 2, SUV39H2 histone lysine methyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Suv39h2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- protein binding activity, bridging
- chromatin binding
- protein binding
- sequence-specific DNA binding
- histone lysine N-methyltransferase activity (H3-K9 specific)
- Pre-SET motif
- protein methyltransferase
- histone methyltransferase
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- binding protein
- zinc ion binding
- double-stranded DNA binding
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- Chromo (CHRromatin organization MOdifier) domain
- N-terminal to some SET domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- migraines
- diabetic nephropathy
role in cell
- expression in
- cell viability
- trimethylation in
- binding
- differentiation
- length
- response by
- binding in
- organization
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- perinuclear region
- nucleoplasm
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Suv39h2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression, epigenetic
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- cell differentiation
- cellular response to hypoxia
- chromatin organization
- circadian rhythm
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone methyltransferase activity (H3-K9 specific)
- transcription regulatory region sequence-specific DNA binding