Cct8 Gene Summary [Mouse]
Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cct8 |
| Official Name | chaperonin containing Tcp1, subunit 8 (theta) [Source:MGI Symbol;Acc:MGI:107183] |
| Ensembl ID | ENSMUSG00000025613 |
| Bio databases IDs | |
| Aliases | chaperonin containing Tcp1, subunit 8 (theta) |
| Synonyms | C21orf112, Cctq, chaperonin containing TCP1 subunit 8, Chaperonin subunit 8, D21S246, PRED71, T-COMPLEX protein 1, THETA subunit, T-COMPLEX protein 1, θ subunit, Tcp1-tau, TCP1 THETA, TCP1 θ, Tcpq |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cct8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- cell death
- binding
- autophagy in
- production in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- intermediate filament cytoskeleton
- secretory granule lumen
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- Nucleus
- centrosome
- microtubules
- cytosol
- nucleoplasm
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cct8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein folding
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- extracellular region
- sperm protein complex
- microtubule
- nucleoplasm
- chaperonin-containing T-complex
- centrosome
- extracellular vesicular exosome
- intermediate filament cytoskeleton
- cytoplasm
- cell body
- cilium
- cytosol
- secretory granule lumen
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding involved in protein folding
- protein binding
- cadherin binding
- unfolded protein binding