Eef1aknmt Gene Summary [Mouse]
Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Is expressed in axial musculature; cochlear ganglion; inner ear; and submandibular gland primordium. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eef1aknmt |
| Official Name | EEF1A lysine and N-terminal methyltransferase [Source:MGI Symbol;Acc:MGI:1918699] |
| Ensembl ID | ENSMUSG00000026694 |
| Bio databases IDs | |
| Aliases | EEF1A lysine and N-terminal methyltransferase |
| Synonyms | 5630401D24Rik, CGI-01, DFNB26, DFNB26M, DFNM1, EEF1AKNMT, feat, KIAA0859, methyltransferase 13, eEF1A lysine and N-terminal methyltransferase, methyltransferase 13, eEF1A N-terminus and K55, RGD1311526 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eef1aknmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-lysine N-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
- Spermine/spermidine synthase domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eef1aknmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein-lysine N-methyltransferase activity